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Article

Virological failure and development of new resistance mutations according to CD4 count at combination antiretroviral therapy initiation.

HIV medicine - 1 May 2016

Jose S, Quinn K, Dunn D, Cox A, Sabin C, Fidler S

Abstract excerpt

OBJECTIVES: No randomized controlled trials have yet reported an individual patient benefit of initiating combination antiretroviral therapy (cART) at CD4 counts > 350 cells/μL. It is hypothesized that earlier initiation of cART in asymptomatic and otherwise healthy individuals may lead to poorer adherence and subsequently higher rates of resistance development. METHODS: In a large cohort of HIV-positive...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26306942
DOI: 10.1111/hiv.12302
PMCID: PMC4949527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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