Article
Oligoribonuclease is a central feature of cyclic diguanylate signaling in Pseudomonas aeruginosa.
Proceedings of the National Academy of Sciences of the United States of America - 8 Sept 2015
Cohen Dorit, Mechold Undine, Nevenzal Hadas, Yarmiyhu Yafit, Randall Trevor E, Bay Denice C, Rich Jacquelyn D, Parsek Matthew R, Kaever Volkhard, Harrison Joe J, Banin Ehud
Abstract excerpt
The second messenger cyclic diguanylate (c-di-GMP) controls diverse cellular processes among bacteria. Diguanylate cyclases synthesize c-di-GMP, whereas it is degraded by c-di-GMP-specific phosphodiesterases (PDEs). Nearly 80% of these PDEs are predicted to depend on the catalytic function of glutamate-alanine-leucine (EAL) domains, which hydrolyze a single phosphodiester group in c-di-GMP to produce...
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