Article
Diribonuclease activity eliminates toxic diribonucleotide accumulation.
Cell reports - 24 Sept 2024
Kim Soo-Kyoung, Orr Mona W, Turdiev Husan, Jenkins Conor C, Lormand Justin D, Myers Tanner M, Burnim Audrey Andy, Carter Jared A, Kung Warren C, Jiang Xiaofang, Sondermann Holger, Winkler Wade C, Lee Vincent T
Abstract excerpt
RNA degradation is a central process required for transcriptional regulation. Eventually, this process degrades diribonucleotides into mononucleotides by specific diribonucleases. In Escherichia coli, oligoribonuclease (Orn) serves this function and is unique as the only essential exoribonuclease. Yet, related organisms, such as Pseudomonas aeruginosa, display a growth defect but are viable without Orn,...
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