Article
Oligoribonuclease is the primary degradative enzyme for pGpG in Pseudomonas aeruginosa that is required for cyclic-di-GMP turnover.
Proceedings of the National Academy of Sciences of the United States of America - 8 Sept 2015
Orr Mona W, Donaldson Gregory P, Severin Geoffrey B, Wang Jingxin, Sintim Herman O, Waters Christopher M, Lee Vincent T
Abstract excerpt
The bacterial second messenger cyclic di-GMP (c-di-GMP) controls biofilm formation and other phenotypes relevant to pathogenesis. Cyclic-di-GMP is synthesized by diguanylate cyclases (DGCs). Phosphodiesterases (PDE-As) end signaling by linearizing c-di-GMP to 5'-phosphoguanylyl-(3',5')-guanosine (pGpG), which is then hydrolyzed to two GMP molecules by yet unidentified enzymes termed PDE-Bs. We show that pGpG...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.