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Article

Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence.

Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2006

Kulasakara Hemantha, Lee Vincent, Brencic Anja, Liberati Nicole, Urbach Jonathan, Miyata Sachiko, Lee Daniel G, Neely Alice N, Hyodo Mamoru, Hayakawa Yoshihiro, Ausubel Frederick M, Lory Stephen

Abstract excerpt

The opportunistic pathogen Pseudomonas aeruginosa is responsible for systemic infections in immunocompromised individuals and chronic respiratory disease in patients with cystic fibrosis. Cyclic nucleotides are known to play a variety of roles in the regulation of virulence-related factors in pathogenic bacteria. A set of P. aeruginosa genes, encoding proteins that contain putative domains characteristic of...

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PMID: 16477007
DOI: 10.1073/pnas.0511090103
PMCID: PMC1413825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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