Article

Cholesterol biosynthetic pathway induces cellular senescence through ERRα

2021-10-20

Abstract excerpt

Cellular senescence is a cell program induced by various stresses that leads to a stable proliferation arrest and to a senescence-associated secretory phenotype. Accumulation of senescent cells during age-related diseases participates in these pathologies and regulates healthy lifespan. Recent evidences point out a global dysregulated intracellular metabolism associated to senescence phenotype. Nonetheless, the fu...

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Literature Corpus work: c104b76e-c2be-5d5e-98f3-7324246d950a
DOI: 10.1101/2021.10.20.465100

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