Article
Telomerase as a Therapeutic Target in Cardiovascular Disease.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2021
Hoffmann Jedrzej, Richardson Gavin, Haendeler Judith, Altschmied Joachim, Andrés Vicente, Spyridopoulos Ioakim
Abstract excerpt
Shortened telomeres have been linked to numerous chronic diseases, most importantly coronary artery disease, but the underlying mechanisms remain ill defined. Loss-of-function mutations and deletions in telomerase both accelerate telomere shortening but do not necessarily lead to a clinical phenotype associated with atherosclerosis, questioning the causal role of telomere length in cardiac pathology. The...
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