Article
Regional Isolation Drives Bacterial Diversification within Cystic Fibrosis Lungs.
Cell host & microbe - 9 Sept 2015
Jorth Peter, Staudinger Benjamin J, Wu Xia, Hisert Katherine B, Hayden Hillary, Garudathri Jayanthi, Harding Christopher L, Radey Matthew C, Rezayat Amir, Bautista Gilbert, Berrington William R, Goddard Amanda F, Zheng Chunxiang, Angermeyer Angus, Brittnacher Mitchell J, Kitzman Jacob, Shendure Jay, Fligner Corinne L, Mittler John, Aitken Moira L, Manoil Colin, Bruce James E, Yahr Timothy L, Singh Pradeep K
Abstract excerpt
Bacterial lineages that chronically infect cystic fibrosis (CF) patients genetically diversify during infection. However, the mechanisms driving diversification are unknown. By dissecting ten CF lung pairs and studying ∼12,000 regional isolates, we were able to investigate whether clonally related Pseudomonas aeruginosa inhabiting different lung regions evolve independently and differ functionally. Phylogenetic...
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