Within-host population structure, migration, and parallel adaptive evolution of Pseudomonas aeruginosa in cystic fibrosis lung disease.

Abstract excerpt

Pseudomonas aeruginosa infections in adults with cystic fibrosis (CF) are comprised of heterogeneous populations, most often tracing ancestry back to a single recent common ancestor. What is not clear is the physical spatial structure within the lung infection population, its stability over time, and whether this physical structure leads to different evolutionary trajectories in different adaptive environments....

Topics

• Cystic Fibrosis
• Pseudomonas aeruginosa
• Humans
• Pseudomonas Infections
• Phylogeny