Article
Patient-derived cell models as preclinical tools for genome-directed targeted therapy.
Oncotarget - 22 Sept 2015
Lee Ji Yun, Kim Sun Young, Park Charny, Kim Nayoung K D, Jang Jiryeon, Park Kyunghee, Yi Jun Ho, Hong Mineui, Ahn Taejin, Rath Oliver, Schueler Julia, Kim Seung Tae, Do In-Gu, Lee Sujin, Park Se Hoon, Ji Yong Ick, Kim Dukwhan, Park Joon Oh, Park Young Suk, Kang Won Ki, Kim Kyoung-Mee, Park Woong-Yang, Lim Ho Yeong, Lee Jeeyun
Abstract excerpt
BACKGROUND: In this study, we established patient-derived tumor cell (PDC) models using tissues collected from patients with metastatic cancer and assessed whether these models could be used as a tool for genome-based cancer treatment. METHODS: PDCs were isolated and cultured from malignant effusions including ascites and pleural fluid. Pathological examination, immunohistochemical analysis, and genomic profiling...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.