Article
Molecular characterization of colorectal cancer patients and concomitant patient-derived tumor cell establishment.
Oncotarget - 12 Apr 2016
Song Haa-Na, Lee Chung, Kim Seung Tae, Kim Sun Young, Kim Nayoung K D, Jang Jiryeon, Kang Mihyun, Jang Hyojin, Ahn Soomin, Kim Seok Hyeong, Park Yoona, Cho Yong Beom, Heo Jeong Wook, Lee Woo Yong, Park Joon Oh, Lim Ho Yeong, Kang Won Ki, Park Young Suk, Park Woong-Yang, Lee Jeeyun, Kim Hee Cheol
Abstract excerpt
BACKGROUND: We aimed to establish a prospectively enrolled colorectal cancer (CRC) cohort for targeted sequencing of primary tumors from CRC patients. In parallel, we established collateral PDC models from the matched primary tumor tissues, which may be later used as preclinical models for genome-directed targeted therapy experiments. RESULTS: In all, we identified 27 SNVs in the 6 genes such as PIK3CA (N = 16),...
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