Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders.

doi:10.1192/bjp.bp.114.154997

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Article

Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders.

The British journal of psychiatry : the journal of mental science - 1 Feb 2016

Lester Kathryn J, Roberts Susanna, Keers Robert, Coleman Jonathan R I, Breen Gerome, Wong Chloe C Y, Xu Xiaohui, Arendt Kristian, Blatter-Meunier Judith, Bögels Susan, Cooper Peter, Creswell Cathy, Heiervang Einar R, Herren Chantal, Hogendoorn Sanne M, Hudson Jennifer L, Krause Karen, Lyneham Heidi J, McKinnon Anna, Morris Talia, Nauta Maaike H, Rapee Ronald M, Rey Yasmin, Schneider Silvia, Schneider Sophie C, Silverman Wendy K, Smith Patrick, Thastum Mikael, Thirlwall Kerstin, Waite Polly, Wergeland Gro Janne, Eley Thalia C

Abstract excerpt

BACKGROUND: We previously reported an association between 5HTTLPR genotype and outcome following cognitive-behavioural therapy (CBT) in child anxiety (Cohort 1). Children homozygous for the low-expression short-allele showed more positive outcomes. Other similar studies have produced mixed results, with most reporting no association between genotype and CBT outcome. AIMS: To replicate the association between...

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PMID: 26294368
DOI: 10.1192/bjp.bp.114.154997
PMCID: PMC4837384

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