Article
Association between 5-HTTLPR genotypes and persisting patterns of anxiety and alcohol use: results from a 10-year longitudinal study of adolescent mental health.
Molecular psychiatry - 1 Sept 2005
Olsson C A, Byrnes G B, Lotfi-Miri M, Collins V, Williamson R, Patton C, Anney R J L
Abstract excerpt
The serotonin transporter gene (5-HTT) encodes a transmembrane protein that plays an important role in regulating serotonergic neurotransmission and related aspects of mood and behaviour. The short allele of a 44 bp insertion/deletion polymorphism (S-allele) within the promoter region of the 5-HTT gene (5-HTTLPR) confers lower transcriptional activity relative to the long allele (L-allele) and may act to modify...
Topics
- Adolescent
- Adult
- Alcohol Drinking
- Anxiety
- Cohort Studies
- Female
- Follow-Up Studies
- Genotype
- Humans
- Longitudinal Studies
- Male