Article
PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.
Cancer discovery - 1 Nov 2015
Liu Pengda, Gan Wenjian, Chin Y Rebecca, Ogura Kohei, Guo Jianping, Zhang Jinfang, Wang Bin, Blenis John, Cantley Lewis C, Toker Alex, Su Bing, Wei Wenyi
Abstract excerpt
UNLABELLED: mTOR serves as a central regulator of cell growth and metabolism by forming two distinct complexes, mTORC1 and mTORC2. Although mechanisms of mTORC1 activation by growth factors and amino acids have been extensively studied, the upstream regulatory mechanisms leading to mTORC2 activation remain largely elusive. Here, we report that the pleckstrin homology (PH) domain of SIN1, an essential and unique...
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