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Article

Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron

17 Jan 2007

Abstract excerpt

The Notch pathway regulates cell fate determination in numerous developmental processes. Here we report that Notch2 acts non-redundantly to control the processes of nephron segmentation through an Rbp-J-dependent process. Notch1 and Notch2 are detected in the early renal vesicle. Genetic analysis reveals that only Notch2 is required for the differentiation of proximal nephron structures (podocytes and proximal...

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PMID: 17229764
DOI: 10.1242/dev.02773

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Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephronPMID 17229764Read ↗

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