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Article

Trans-Reactivation: A New Epigenetic Phenomenon Underlying Transcriptional Reactivation of Silenced Genes.

PLoS genetics - 1 Aug 2015

Onorati Maria Cristina, Arancio Walter, Cavalieri Vincenzo, Ingrassia Antonia M R, Pavesi Giulio, Corona Davide F V

Abstract excerpt

In order to study the role played by cellular RNA pools produced by homologous genomic loci in defining the transcriptional state of a silenced gene, we tested the effect of non-functional alleles of the white gene in the presence of a functional copy of white, silenced by heterochromatin. We found that non-functional alleles of white, unable to produce a coding transcript, could reactivate in trans the...

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Identifiers

PMID: 26292210
DOI: 10.1371/journal.pgen.1005444
PMCID: PMC4546373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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