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Article

Sequence elements in cis influence heterochromatic silencing in trans.

Molecular and cellular biology - 1 Jan 2005

Sage Brian T, Jones John L, Holmes Amy L, Wu Michael D, Csink Amy K

Abstract excerpt

The brown(Dominant) (bw(D)) allele contains a large insertion of heterochromatin, which causes the locus to aberrantly associate with heterochromatin in interphase nuclei and silences the wild-type allele in heterozygotes. Transgenes placed near the bw(+) locus, in trans to bw(D), can also be silenced. The strength of silencing (called trans inactivation) varies with the regulatory sequences of the transgene and...

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Source

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Identifiers

PMID: 15601858
DOI: 10.1128/MCB.25.1.377-388.2005
PMCID: PMC538776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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