Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss and Gain of Natural Killer Cell Receptor Function in an African Hunter-Gatherer Population.

PLoS genetics - 1 Aug 2015

Hilton Hugo G, Norman Paul J, Nemat-Gorgani Neda, Goyos Ana, Hollenbach Jill A, Henn Brenna M, Gignoux Christopher R, Guethlein Lisbeth A, Parham Peter

Abstract excerpt

Modulating natural killer cell functions in human immunity and reproduction are diverse interactions between the killer cell immunoglobulin-like receptors (KIR) of Natural Killer (NK) cells and HLA class I ligands on the surface of tissue cells. Dominant interactions are between KIR2DL1 and the C2 epitope of HLA-C and between KIR2DL2/3 and the C1 epitope of HLA-C. KhoeSan hunter-gatherers of Southern Africa...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Evolution, Molecular
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetics, Medical

Share to HeLa Cells

Share to Killer Cells, Natural

Share to Linkage Disequilibrium

Share to Receptors, KIR2DL1

Share to South Africa

Source

Open in PubMed Open full text

Identifiers

PMID: 26292085
DOI: 10.1371/journal.pgen.1005439
PMCID: PMC4546388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss and Gain of Natural Killer Cell Receptor Function in an African Hunter-Gatherer Population.PMID 26292085Read ↗

Deciphering the killer-cell immunoglobulin-like receptor system at super-resolution for natural killer and T-cell biology.Semantic proximity Read ↗

The genetic and evolutionary balances in human NK cell receptor diversity.Semantic proximity Read ↗

Resurrecting KIR2DP1: A Key Intermediate in the Evolution of Human Inhibitory NK Cell Receptors That Recognize HLA-C.Semantic proximity Read ↗

Killer cell immunoglobulin-like receptor (KIR) genes and their HLA-C ligands in a Ugandan population.Semantic proximity Read ↗

Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations.Semantic proximity Read ↗

KIR: diverse, rapidly evolving receptors of innate and adaptive immunity.Semantic proximity Read ↗

Genetics of Natural Killer Cells in Human Health, Disease, and Survival.Semantic proximity Read ↗

Polymorphic HLA-C Receptors Balance the Functional Characteristics of KIR Haplotypes.Semantic proximity Read ↗

KIR2DS5 allotypes that recognize the C2 epitope of HLA-C are common among Africans and absent from Europeans.Semantic proximity Read ↗

Killer cell immunoglobulin-like receptor diversity: balancing signals in the natural killer cell response.Semantic proximity Read ↗

Hanging in the balance. KIR and their role in disease.Semantic proximity Read ↗

Identification of four novel KIR2DL2 alleles and two novel KIR2DL3 alleles in an East African population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.