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Hepatitis B Virus Combo Mutations Improve the Prediction and Active Prophylaxis of Hepatocellular Carcinoma: A Clinic-Based Cohort Study.

Cancer prevention research (Philadelphia, Pa.) - 1 Oct 2015

Yin Jianhua, Wang Junxue, Pu Rui, Xin Haiguang, Li Zixiong, Han Xue, Ding Yibo, Du Yan, Liu Wenbin, Deng Yang, Ji Xiaowei, Wu Ming, Yu Min, Zhang Hongwei, Wang Hongyang, Thompson Timothy C, Ni Wu, Cao Guangwen

Abstract excerpt

We aimed to evaluate whether hepatitis B virus (HBV) mutations at the core promoter region could improve the prediction and specific prophylaxis of hepatocellular carcinoma (HCC) in chronic HBV-infected patients. A total of 2,114 HBV-infected patients enrolled between August 1998 and December 2007 were followed-up for 18,406 person-years. Of those, 612 received ≥48 week treatments with nucleos(t)ide analogue (NA)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26290395
DOI: 10.1158/1940-6207.CAPR-15-0160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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