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In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response

20 Aug 2015

Abstract excerpt

The high-risk human papillomavirus E6 (hrHPV E6) protein has been widely studied due to its implication in cervical cancer. In response to viral threat, activated kinases phosphorylate the IRF3 autoinhibitory domain, inducing type1 interferon production. HPV circumvents the antiviral response through the possible E6 interaction with IRF3 and abrogates p53's apoptotic activity by recruiting E6-associated protein....

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PMID: 26289783
DOI: 10.1038/srep13446

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