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Article

Deciphering the mechanisms of HPV E6 mutations in the destabilization of E6/E6AP/p53 complex.

Biophysical journal - 3 May 2022

Li Le, Dong Xuewei, Tang Yiming, Lao Zenghui, Li Xuhua, Lei Jiangtao, Wei Guanghong

Abstract excerpt

In epithelial tumors, oncoprotein E6 binds with the ubiquitin ligase E6AP to form E6/E6AP heterodimer; then this heterodimer recruits p53 to form E6/E6AP/p53 heterotrimer and induces p53 degradation. Recent experiments demonstrated that three E6 single-site mutants (F47R, R102A, and L50E) can inhibit the E6/E6AP/p53 heterotrimer formation and rescue p53 from the degradation pathway. However, the molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35364103
DOI: 10.1016/j.bpj.2022.03.030
PMCID: PMC9117921

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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