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Article

Cascade of deoxyribozymes for the colorimetric analysis of drug resistance in Mycobacterium tuberculosis.

Biosensors & bioelectronics - 1 Oct 2020

Dhar Bidhan C, Reed Adam J, Mitra Suvra, Rodriguez Sanchez Patricia, Nedorezova Daria D, Connelly Ryan P, Rohde Kyle H, Gerasimova Yulia V

Abstract excerpt

A visual cascade detection system has been applied to the detection and analysis of drug-resistance profile of Mycobacterium tuberculosis complex (MTC), a causative agent of tuberculosis. The cascade system utilizes highly selective split RNA-cleaving deoxyribozyme (sDz) sensors. When activated by a complementary nucleic acid, sDz releases the peroxidase-like deoxyribozyme apoenzyme, which, in complex with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32729510
DOI: 10.1016/j.bios.2020.112385
PMCID: PMC7484165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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