Article
CD8 and CD4 epitope predictions in RV144: no strong evidence of a T-cell driven sieve effect in HIV-1 breakthrough sequences from trial participants.
PloS one - 1 Jan 2014
Dommaraju Kalpana, Kijak Gustavo, Carlson Jonathan M, Larsen Brendan B, Tovanabutra Sodsai, Geraghty Dan E, Deng Wenjie, Maust Brandon S, Edlefsen Paul T, Sanders-Buell Eric, Ratto-Kim Silvia, deSouza Mark S, Rerks-Ngarm Supachai, Nitayaphan Sorachai, Pitisuttihum Punnee, Kaewkungwal Jaranit, O'Connell Robert J, Robb Merlin L, Michael Nelson L, Mullins James I, Kim Jerome H, Rolland Morgane
Abstract excerpt
The modest protection afforded by the RV144 vaccine offers an opportunity to evaluate its mechanisms of protection. Differences between HIV-1 breakthrough viruses from vaccine and placebo recipients can be attributed to the RV144 vaccine as this was a randomized and double-blinded trial. CD8 and CD4 T cell epitope repertoires were predicted in HIV-1 proteomes from 110 RV144 participants. Predicted Gag epitope...
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