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Article

Catecholaminergic Gene Polymorphisms Are Associated with GI Symptoms and Morphological Brain Changes in Irritable Bowel Syndrome.

PloS one - 1 Jan 2015

Orand Alexa, Gupta Arpana, Shih Wendy, Presson Angela P, Hammer Christian, Niesler Beate, Heendeniya Nuwanthi, Mayer Emeran A, Chang Lin

Abstract excerpt

BACKGROUND: Genetic and environmental factors contribute to the pathophysiology of irritable bowel syndrome (IBS). In particular, early adverse life events (EALs) and the catecholaminergic system have been implicated. AIMS: To investigate whether catecholaminergic SNPs with or without interacting with EALs are associated with: 1) a diagnosis of IBS, 2) IBS symptoms and 3) morphological alterations in brain...

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Identifiers

PMID: 26288143
DOI: 10.1371/journal.pone.0135910
PMCID: PMC4546052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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