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Article

Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2011

Mattapallil Mary J, Silver Phyllis B, Mattapallil Joseph J, Horai Reiko, Karabekian Zaruhi, McDowell J Hugh, Chan Chi-Chao, James Eddie A, Kwok William W, Sen H Nida, Nussenblatt Robert B, David Chella S, Caspi Rachel R

Abstract excerpt

Noninfectious uveitis is a leading cause of blindness and thought to involve autoimmune T cell responses to retinal proteins (e.g., retinal arrestin [soluble-Ag (S-Ag)]). There are no known biomarkers for the disease. Susceptibility is associated with HLA, but little is known about susceptible class II alleles or the potentially pathogenic epitopes that they present. Using a humanized HLA-transgenic mouse model...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

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Source

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Identifiers

PMID: 21765017
DOI: 10.4049/jimmunol.1101247
PMCID: PMC3150271

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