Article
Less Frequent and Less Severe Flu-Like Syndrome in Interferon Beta-1a Treated Multiple Sclerosis Patients with at Least One Allele Bearing the G>C Polymorphism at Position -174 of the IL-6 Promoter Gene.
PloS one - 1 Jan 2015
Bertoli Diego, Serana Federico, Sottini Alessandra, Cordioli Cinzia, Maimone Davide, Amato Maria Pia, Centonze Diego, Florio Ciro, Puma Elisa, Capra Ruggero, Imberti Luisa
Abstract excerpt
One of the most common adverse event of interferon beta (IFNβ) therapy for multiple sclerosis is flu-like syndrome (FLS), which has been reportedly related to increased levels of cytokines such as interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Average cytokine levels can be affected by single nucleotide polymorphism in the gene promoter regions. To investigate whether IL-6 -174 G>C and TNF-α -376...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.