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Article

TRPV1 polymorphisms and risk of interferon β-induced flu-like syndrome in patients with relapsing-remitting multiple sclerosis.

Journal of neuroimmunology - 15 Apr 2017

Buttari Fabio, Zagaglia Sara, Marciano Lorenzo, Albanese Maria, Landi Doriana, Nicoletti Carolina Gabri, Mercuri Nicola Biagio, Silvestrini Mauro, Provinciali Leandro, Marfia Girolama Alessandra, Mori Francesco, Centonze Diego

Abstract excerpt

Interferon-β (IFN-β) is often discontinued in RRMS patients due to its most common side effect, the flu-like syndrome (FLS). The mechanisms underlying IFN β-induced FLS symptoms are still unclear. The endocannabinoid system (ECS) is a key regulator of pain and inflammation. Thus we tested the hypothesis that the ECS could be involved in FLS severity by exploring the effect of genetic polymorphisms with functional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 28284340
DOI: 10.1016/j.jneuroim.2017.02.007

Genes

TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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