Article
Identification and characterisation of cancer genes.
British medical bulletin - 1 Jul 1994
Steel C M
Abstract excerpt
Cancer genes have been subdivided into oncogenes and tumour suppressors though the distinction is not entirely valid. In many cases their effects can be demonstrated by induction or reversal of a transformed phenotype following transfection into a suitable host cell but full characterisation requires isolation by positional cloning and analysis of function at the molecular level. Almost all have been ascribed...
Topics
- Cloning, Molecular
- Cytogenetics
- DNA Mutational Analysis
- Gene Expression
- Genetic Linkage
- Humans
- Mutation
- Neoplasms
- Oncogenes
- Pedigree
- Proteins