Article
[Tumor suppressor genes: occurrence, significance and function].
Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde - 1 Oct 1991
Scheurlen W, Kreth H W
Abstract excerpt
Tumor-suppressor-genes were detected by DNA-analysis of childhood tumors. A homozygous deletion or mutation of these genes is closely associated with different malignant tumors. Tumor-suppressor-genes seem to play an important role in cellular development and differentiation. The understanding of this pathomechanism in cancerogenesis is most important for calculating a genetic risk for tumor development.
Topics
- Biomarkers, Tumor
- Cell Transformation, Neoplastic
- Child
- Chromosome Deletion
- Eye Neoplasms
- Genes, Tumor Suppressor
- Humans
- Kidney Neoplasms
- Mutation
- Neoplasms
- Retinoblastoma