[Studies on tumor suppressor genes by gene/chromosome transfer].

Abstract excerpt

The gene/chromosome transfer into cultured cancer cells has not only confirmed that genes isolated by the positional cloning method can actually suppress various transformed phenotypes of the cells, but also allowed to speculate cellular functions of cloned or uncloned tumor suppressor genes. One of the important functions of uncloned ones is to induce the cellular senescence program in immortal cancer cells, as...

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