Transmission Disequilibrium Tests Based on Read Counts for Low-Coverage Next-Generation Sequence Data.

Abstract excerpt

The purpose of this paper is the introduction of new statistical methods for case-parent trio association studies based on the read counts that can be obtained from next-generation sequencing (NGS) experiments. This work focuses on the inclusion of low-coverage data into the case-parent trio design without genotype classification or imputation. Two different approaches are considered: (1) a likelihood-based...

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