Article
Novel evidence of association with nonsyndromic cleft lip with or without cleft palate was shown for single nucleotide polymorphisms in FOXF2 gene in an Asian population.
Birth defects research. Part A, Clinical and molecular teratology - 1 Oct 2015
Bu Lingxue, Chen Qianqian, Wang Hong, Zhang Tianxiao, Hetmanski Jacqueline B, Schwender Holger, Parker Margaret, Chou Yah-Huei Wu, Yeow Vincent, Chong Samuel S, Zhang Bo, Jabs Ethylin Wang, Scott Alan F, Beaty Terri H
Abstract excerpt
BACKGROUND: The forkhead box F2 gene (FOXF2) located in chromosome 6p25.3 has been shown to play a crucial role in palatal development in mouse and rat models. To date, no evidence of linkage or association has been reported for this gene in humans with oral clefts. METHODS: Allelic transmission disequilibrium tests were used to robustly assess evidence of linkage and association with nonsyndromic cleft lip with...
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