Article
Functional genetic variability at promoters of pro-(IL-18) and anti-(IL-10) inflammatory affects their mRNA expression and survival in prostate carcinoma patients: Five year follow-up study.
The Prostate - 1 Nov 2015
Dwivedi Shailendra, Goel Apul, Mandhani Anil, Khattri Sanjay, Sharma Praveen, Misra Sanjeev, Pant Kamlesh Kumar
Abstract excerpt
BACKGROUND: Inflammation is an important hallmark of all cancers. The net inflammatory response is determined by a delicate balance between pro- and anti-inflammatory cytokines, which, in turn, is determined by the genetic make-up. The present study investigates the role of variations in the promoter regions of IL-18 and IL-10 (anti-inflammatory) cytokines on mRNA expressions and survival in prostate cancer (PCa)...
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