Article
Pro-(IL-18) and Anti-(IL-10) Inflammatory Promoter Genetic Variants (Intrinsic Factors) with Tobacco Exposure (Extrinsic Factors) May Influence Susceptibility and Severity of Prostate Carcinoma: A Prospective Study.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2015
Dwivedi Shailendra, Singh Sarvesh, Goel Apul, Khattri Sanjay, Mandhani Anil, Sharma Praveen, Misra Sanjeev, Pant Kamlesh Kumar
Abstract excerpt
BACKGROUND: It has been hypothesized that IL-18 (pro-) and IL-10 (anti-) inflammatory genetic variants at -607 C/A-137G/C and -819C/T,-592C/A, respectively, may generate susceptibility and severity risk with various modes of tobacco exposure in prostate carcinoma (PCa) patients. IL-18 is a pro-inflammatory cytokine expressed on various cells including prostate gland elements, and is a key mediator of immune...
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