Article
Morphologically occult systemic mastocytosis in bone marrow: clinicopathologic features and an algorithmic approach to diagnosis.
American journal of clinical pathology - 1 Sept 2015
Reichard Kaaren K, Chen Dong, Pardanani Animesh, McClure Rebecca F, Howard Matthew T, Kurtin Paul J, Wood Adam J, Ketterling Rhett P, King Rebecca L, He Rong, Morice William G, Hanson Curtis A
Abstract excerpt
OBJECTIVES: Bone marrow (BM) biopsy specimens involved by systemic mastocytosis (SM) typically show multifocal, compact, dense aggregates of spindled mast cells (MCs). However, some cases lack aggregate formation and fulfill the World Health Organization 2008 criteria for SM, based on minor criteria. METHODS: We identified 26 BM cases of KIT D816V-mutated, morphologically occult SM in the BM. RESULTS: All...
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