Clinical, biological, and molecular characteristics of clonal mast cell disorders presenting with systemic mast cell activation symptoms.

doi:10.1016/j.jaci.2010.02.019

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Article

Clinical, biological, and molecular characteristics of clonal mast cell disorders presenting with systemic mast cell activation symptoms.

The Journal of allergy and clinical immunology - 1 Jun 2010

Alvarez-Twose Iván, González de Olano David, Sánchez-Muñoz Laura, Matito Almudena, Esteban-López Maria I, Vega Arantza, Mateo Maria Belén, Alonso Díaz de Durana Maria D, de la Hoz Belén, Del Pozo Gil Maria D, Caballero Teresa, Rosado Ana, Sánchez Matas Isabel, Teodósio Cristina, Jara-Acevedo María, Mollejo Manuela, García-Montero Andrés, Orfao Alberto, Escribano Luis

Abstract excerpt

BACKGROUND: Systemic mast cell activation disorders (MCADs) are characterized by severe and systemic mast cell (MC) mediators-related symptoms frequently associated with increased serum baseline tryptase (sBt). OBJECTIVE: To analyze the clinical, biological, and molecular characteristics of adult patients presenting with systemic MC activation symptoms/anaphylaxis in the absence of skin mastocytosis who showed...

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PMID: 20434205
DOI: 10.1016/j.jaci.2010.02.019

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