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Article

UVA-mediated down-regulation of MMP-2 and MT1-MMP coincides with impaired angiogenic phenotype of human dermal endothelial cells.

Biochemical and biophysical research communications - 30 Jun 2006

Cauchard Jean-Hubert, Robinet Arnaud, Poitevin Stéphane, Bobichon Hélene, Maziere Jean-Claude, Bellon Georges, Hornebeck William

Abstract excerpt

UVA irradiation, dose-dependently (5-20 J/cm2), was shown to impair the morphogenic differentiation of human microvascular endothelial cells (HMECs) on Matrigel. Parallely, UVA down-regulated the expression of MMP-2 and MT1-MMP, both at the protein and the mRNA levels. On the contrary, the production of MMP-1 and TIMP-1 by HMECs increased following UVA treatment. The inhibitory effect of UVA on MMP expression and...

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Identifiers

PMID: 16696942
DOI: 10.1016/j.bbrc.2006.04.115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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