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Dimethyloxalylglycine Stabilizes HIF-1α in Cultured Human Endothelial Cells and Increases Random-Pattern Skin Flap Survival In Vivo

26 Jul 2011

Abstract excerpt

BACKGROUND: The goal of this study was to evaluate in vitro and in vivo the effects of up-regulation of the proangiogenic hypoxia inducible factor (HIF)-1α induced by dimethyloxalylglycine on endothelial cell cultures and on skin flap survival. METHODS: Human umbilical vein endothelial cell cultures were exposed to hypoxic conditions, to dimethyloxalylglycine, and to cobalt chloride for up to 24 hours. Expression...

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PMID: 21788833
DOI: 10.1097/prs.0b013e31821e6e69

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