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Article

Three-dimensional spheroid cell culture of umbilical cord tissue-derived mesenchymal stromal cells leads to enhanced paracrine induction of wound healing.

Stem cell research & therapy - 9 May 2015

Santos Jorge M, Camões Sérgio P, Filipe Elysse, Cipriano Madalena, Barcia Rita N, Filipe Mariana, Teixeira Mariana, Simões Sandra, Gaspar Manuela, Mosqueira Diogo, Nascimento Diana S, Pinto-do-Ó Perpétua, Cruz Pedro, Cruz Helder, Castro Matilde, Miranda Joana P

Abstract excerpt

INTRODUCTION: The secretion of trophic factors by mesenchymal stromal cells has gained increased interest given the benefits it may bring to the treatment of a variety of traumatic injuries such as skin wounds. Herein, we report on a three-dimensional culture-based method to improve the paracrine activity of a specific population of umbilical cord tissue-derived mesenchymal stromal cells (UCX®) towards the...

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Identifiers

PMID: 25956381
DOI: 10.1186/s13287-015-0082-5
PMCID: PMC4448539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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