Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estradiol regulates human QT-interval: acceleration of cardiac repolarization by enhanced KCNH2 membrane trafficking

12 Aug 2015

Abstract excerpt

BACKGROUND: Modulation of cardiac repolarization by sexual hormones is controversial and hormonal effects on ion channels remain largely unknown. In the present translational study, we therefore assessed the relationship between QTc duration and gonadal hormones and studied underlying mechanisms. METHODS AND RESULTS: We measured hormone levels and QTc intervals in women during clomiphene stimulation for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac electrophysiology and arrhythmias
Share to Takotsubo Cardiomyopathy and Associated Phenomena
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26271031
DOI: 10.1093/eurheartj/ehv371

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estradiol regulates human QT-interval: acceleration of cardiac repolarization by enhanced KCNH2 membrane traffickingPMID 26271031Read ↗

Ca2+ current involvement in a KCNH2 mutation's phenotype and its modulation by estrogen.Semantic proximity Read ↗

Co-chaperone FKBP38 promotes HERG trafficking.Semantic proximity Read ↗

The impact of testosterone on the QT interval: A Systematic reviewSemantic proximity Read ↗

CAVIN1-Mediated Endocytosis: A Novel Mechanism Underlying The Interindividual Variability In Drug-Induced Long QTSemantic proximity Read ↗

Long-QT mutations in KCNE1 modulate the 17β-estradiol response of Kv7.1/KCNE1.Semantic proximity Read ↗

Long QT syndrome. Why does sex matter?Semantic proximity Read ↗

Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG.Semantic proximity Read ↗

Sex-specific amplification of <i>I</i> <sub>Kr</sub> -blocker–induced action potential prolongation by reduced female <i>I</i> <sub>Ks</sub> repolarization reserve: a computational study using the O’Hara-Rudy human ventricular modelSemantic proximity Read ↗

Genomic upregulation of cardiac Cav1.2α and NCX1 by estrogen in womenSemantic proximity Read ↗

Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine.Semantic proximity Read ↗

Long QT syndrome-associated I593R mutation in HERG potassium channel activates ER stress pathways.Semantic proximity Read ↗

Association between HERG K897T polymorphism and QT interval in middle-aged Finnish women.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.