Article
Late emergence of A594V and L595W mutations related to ganciclovir resistance in a patient with HCMV retinitis and long-term HIV progression.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Sept 2015
Slavov S N, Vilar F C, Wagatsuma V M D, Santana R C, Machado A A, Fonseca B A L da, Kashima S, Covas D T
Abstract excerpt
The emergence of ganciclovir (GCV) resistance during the treatment of human cytomegalovirus (HCMV) infection is a serious clinical challenge, and is associated with high morbidity and mortality. In this case report, we describe the emergence of two consecutive mutations (A594V and L595W) related to GCV resistance in a patient with HCMV retinitis and long-term HIV progression after approximately 240 days of GCV...
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