The role for gut permeability in the pathogenesis of type 1 diabetes - a solid or leaky concept?

Abstract excerpt

Increasing evidence, both functional and morphological, supports the concept of increased intestinal permeability as an intrinsic characteristic of type 1 diabetes (T1D) in both humans and animal models of the disease. Often referred to as a 'leaky gut', its mechanistic impact on the pathogenesis of T1D remains unclear. Hypotheses that this defect influences immune responses against antigens (both self and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Diabetes and associated disorders
• Share to Diabetes Management and Research
• Share to Diet and metabolism studies