Article
KIF5B-RET Fusion gene may coincide oncogenic mutations of EGFR or KRAS gene in lung adenocarcinomas.
Diagnostic pathology - 14 Aug 2015
Kim Jeong-Oh, Lee Jieun, Shin Jung-Young, Oh Ji-Eun, Jung Chan-Kwon, Park Jae Kil, Sung Sook-Whan, Bae Sang-Ju, Min Hyun-Jung, Kim Dowon, Park Jae Yong, Kang Jin-Hyoung
Abstract excerpt
BACKGROUND: The KIF5B-RET rearrangement is detected with the frequency of 1 ~ 2% in 'triple marker'-negative lung adenocarcinomas, i.e., EGFR, KRAS and EML4-ALK wild type. These mutational changes are known to be mutually exclusive, but the co-existence of ALK rearrangement with activating mutations of EGFR is rarely found. METHODS: We examined the KIF5B-RET fusion gene in frozen tissues from 154 surgically...
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