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Article

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer.

1 Apr 2015

Abstract excerpt

Fusions of the RET and ROS1 protein tyrosine kinase oncogenes with several partner genes were recently identified as new targetable genetic aberrations in cases of non-small cell lung cancer (NSCLC) lacking activating EGFR, KRAS, ALK, BRAF, or HER2 oncogene aberrations. RET and ROS1 fusion-positive tumors are mainly observed in young, female, and/or never smoking patients. Studies based on in vitro and in vivo...

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Identifiers

PMID: 25870798
DOI: 10.3978/j.issn.2218-6751.2014.11.11

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