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Article

KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer

21 Jul 2014

Abstract excerpt

BACKGROUND: Lung cancer in nonsmokers tends to be driven by a single somatic mutation or a gene fusion. KIF5B-RET fusion is an oncogene identified in non-small cell lung cancers. In this study, we verified the oncogenic activity of KIF5B-RET fusion and investigated how KIF5B-RET activates the specific signaling pathways for cellular transformation. We aimed to provide a basis for the further development of the...

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PMID: 25047660
DOI: 10.1186/1476-4598-13-176

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