Article
Mutation analysis in the coding sequence of thymidine kinase 1 in breast and colorectal cancer.
The International journal of biological markers - 1 Jan 2000
Gilles S I, Romain S, Casellas P, Ouafik L'H, Fina F, Combes T, Vuaroquaux V, Seitz J F, Bonnier P, Galiègue S, Carayon P, Martin P M
Abstract excerpt
We report the first mutational study of thymidine kinase 1 (TK1) performed in human solid tumors. We sequenced cDNAs representing the complete coding region of TK1 in human breast (n=22) and colorectal (n=26) cancer. Codon 106 near the ATP binding site constantly differed (ATG --> GTG; Met --> Val) from the one deposited by Bradshaw and Deininger in the Genbank database (Accession number NM_003258). Silent...
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