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Article

Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2010

Kimple Randall J, Vaseva Angelina V, Cox Adrienne D, Baerman Kathryn M, Calvo Benjamin F, Tepper Joel E, Shields Janiel M, Sartor Carolyn I

Abstract excerpt

PURPOSE: Epidermal growth factor receptor (EGFR) family members (e.g., EGFR, HER2, HER3, and HER4) are commonly overexpressed in pancreatic cancer. We investigated the effects of inhibition of EGFR/HER2 signaling on pancreatic cancer to elucidate the role(s) of EGFR/HER2 in radiosensitization and to provide evidence in support of further clinical investigations. EXPERIMENTAL DESIGN: Expression of EGFR family...

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Identifiers

PMID: 20103665
DOI: 10.1158/1078-0432.CCR-09-1324
PMCID: PMC2818631

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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