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Article

Dominant negative MEKK1 inhibits survival of pancreatic cancer cells.

Oncogene - 29 Aug 2002

Hirano Tatsuya, Shino Yuji, Saito Takeshi, Komoda Fumitake, Okutomi Yoshiyuki, Takeda Akiko, Ishihara Takeshi, Yamaguchi Taketo, Saisho Hiromitsu, Shirasawa Hiroshi

Abstract excerpt

Human pancreatic cancers harbor mutations in the K-ras gene, and these mutations convert the gene oncogenic and constitutively active forms. However, in pancreatic cancer cells little is known about the activation of the downstream pathways of Ras, MEK-ERK and MEKK1-JNK, and their roles in cell survival and proliferation. An analysis of nine pancreatic cancer tissues revealed JNK activation in all tumor samples...

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Identifiers

PMID: 12185592
DOI: 10.1038/sj.onc.1205643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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