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Article

P-selectin gene polymorphism associates with pulmonary hypertension in congenital heart disease.

International journal of clinical and experimental pathology - 1 Jan 2015

Li Xiao-Fei, Song Chun-Hui, Sheng Hong-Zhuan, Zhen Dong-Dong, Pan Min, Zhu Jian-Hua

Abstract excerpt

OBJECTIVE: To investigate the relationship between P-selectin gene polymorphism and congenital heart disease (CHD) with pulmonary hypertension (PAH). METHODS: 58 CHD patients with PAH (PAH-CHD), 43 CHD patients without PAH and 205 healthy subjects were included in this study. The concentration of plasma P-selectin was determined by ELISA kits; the direct sequencing of PCR products was used to analyze the...

Topics

Adolescent
Adult
Case-Control Studies
Chi-Square Distribution
Enzyme-Linked Immunosorbent Assay
Female
Gene Frequency
Genetic Association Studies
Genetic Markers
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heart Defects, Congenital

Heterozygote

Homozygote

Humans

Hypertension, Pulmonary

Logistic Models

Male

Middle Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 26261613
PMCID: PMC4525947

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26261613-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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