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Article

High Frequency of Pulmonary Hypertension-Causing Gene Mutation in Chinese Patients with Chronic Thromboembolic Pulmonary Hypertension.

PloS one - 1 Jan 2016

Xi Qunying, Liu Zhihong, Zhao Zhihui, Luo Qin, Huang Zhiwei

Abstract excerpt

The pathogenesis of chronic thromboembolic pulmonary hypertension (CTEPH) is unknown. Histopathologic studies revealed that pulmonary vasculature lesions similar to idiopathic pulmonary arterial hypertension (PAH) existed in CTEPH patients as well. It's well-known that genetic predisposition plays an important role in the mechanism of PAH. So we hypothesized that PAH-causing gene mutation might exist in some...

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Source

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Identifiers

PMID: 26820968
DOI: 10.1371/journal.pone.0147396
PMCID: PMC4731080

Genes

PAH
ACVRL1
BMPR2
CAV1
CBLN2
ENG
KCNK3
SMAD9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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